Brazil up against Uruguay, Argentina take on Peru
However, having faced the three bottom teams so far, their place atop the single 10-team CONMEBOL qualifying group will come under threat when they play in Montevideo against a Uruguay team that purred in a 3-0 thumping of Colombia on Friday.
Brazil will need to up their game as they face another match without Paris Saint-Germain forward Neymar, who suffered a thigh injury last month and is still not fit.
"We have had three victories. In the first two we created lots of chances and scored lots of goals, played well and got good results," Tite said in a virtual press conference on Monday.
"We might not have played well in the third game (against Venezuela) but it was a consistent performance and we got the win. Maybe these teams won't be in the running to qualify but they will soon climb the table."
He added: "This is traditionally a big game. Uruguay on their own turf are a different proposition and will make more demands of us defensively than Venezuela did, but at the same time we will have more space in which to create going forward."
Tite struggled to find the right formula to break down Venezuela in Sao Paulo, with Firmino withdrawing to a deeper role on the left, Richarlison starting as centre forward and Gabriel Jesus on the right.
Messi, Argentina go to Peru